This site is under re-construction.
I have been a scientist ever since I remember, spending most of my professional life in academia studying basic biological problems based on genomics and bioinformatics. Now that I am the CEO of a company, I have little time for hard core research, but I am fortunate to still be able to participate in my own company’s very applied research.
Scientific publications indexed on PubMed
, 2023. BRCA1 VUS: A functional analysis to differentiate pathogenic from benign variants identified in clinical diagnostic panels for breast cancer. Mol Med Rep 28.
, 2022. A Gene Expression Signature to Select Hepatocellular Carcinoma Patients for Liver Transplantation. Ann Surg 276(5):868-874
, 2022. Impact of Beer and Nonalcoholic Beer Consumption on the Gut Microbiota: A Randomized, Double-Blind, Controlled Trial. J Agric Food Chem 70(41):13062-13070
, 2022. DNA methylation fingerprint of hepatocellular carcinoma from tissue and liquid biopsies. Sci Rep 12(1):11512
, 2021. Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients. Front Microbiol 12:705020
, 2021. A Pilot Study on the Metabolic Impact of Mediterranean Diet in Type 2 Diabetes: Is Gut Microbiota the Key? Nutrients 13.
, 2020. A novel cyanobacterial geosmin producer, revising GeoA distribution and dispersion patterns in Bacteria. Sci Rep 10(1):8679
, 2019. Pericentrin-mediated SAS-6 recruitment promotes centriole assembly. Elife 8.
, 2019. Disulfiram, an alcohol dependence therapy, can inhibit the in vitro growth of Francisella tularensis. Int J Antimicrob Agents 54(1):85-88
, 2019. Diversity and Composition of Pelagic Prokaryotic and Protist Communities in a Thin Arctic Sea-Ice Regime. Microb Ecol 78(2):388-408
, 2018. Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis. J Cell Biol 217(7):2353-2363
, 2018. Microbial Diversity and Toxin Risk in Tropical Freshwater Reservoirs of Cape Verde. Toxins (Basel) 10.
, 2018. Collective electrical oscillations of a diatom population induced by dark stress. Sci Rep 8(1):5484
, 2018. Genetic Competence Drives Genome Diversity in Bacillus subtilis. Genome Biol Evol 10(1):108-124
, 2017. Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells. Nat Commun 8:15237
, 2017. Rabifier2: an improved bioinformatic classifier of Rab GTPases. Bioinformatics 33(4):568-570
, 2017. Does Hypoxic Response Mediate Primary Resistance to Sunitinib in Untreated Locally Advanced Breast Cancer? Curr Cancer Drug Targets 17(1):62-73
, 2016. RAG Recombinase as a Selective Pressure for Genome Evolution. Genome Biol Evol 8(11):3364-3376
, 2016. CYR61 and TAZ Upregulation and Focal Epithelial to Mesenchymal Transition May Be Early Predictors of Barrett's Esophagus Malignant Progression. PLoS One 11(9):e0161967
, 2016. Are There Rab GTPases in Archaea? Mol Biol Evol 33(7):1833-42
, 2015. Gene Tree Affects Inference of Sites Under Selection by the Branch-Site Test of Positive Selection. Evol Bioinform Online 11(Suppl 2):11-7
, 2015. Coiled-coil length: Size does matter. Proteins 83(12):2162-9
, 2015. Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance. PLoS Pathog 11(5):e1004891
, 2015. Rethinking the Niche of Upper-Atmosphere Bacteria: Draft Genome Sequences of Bacillus aryabhattai C765 and Bacillus aerophilus C772, Isolated from Rice Fields. Genome Announc 3.
, 2015. Bioinformatic approaches to identifying and classifying Rab proteins. Methods Mol Biol 1298:17-28
, 2015. Evolutionary patterns in coiled-coils. Genome Biol Evol 7(2):545-56
, 2014. Evolutionary cell biology: two origins, one objective. Proc Natl Acad Sci U S A 111(48):16990-4
, 2014. Hope for GWAS: relevant risk genes uncovered from GWAS statistical noise. Int J Mol Sci 15(10):17601-21
, 2014. A comprehensive assessment of the transcriptome of cork oak (Quercus suber) through EST sequencing. BMC Genomics 15(1):371
, 2014. Bioinformatics projects supporting life-sciences learning in high schools. PLoS Comput Biol 10(1):e1003404
, 2013. inTB - a data integration platform for molecular and clinical epidemiological analysis of tuberculosis. BMC Bioinformatics 14:264
, 2013. SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil. Infect Genet Evol 18:238-46
, 2013. Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle. Open Biol 3(3):120185
, 2013. Genome of a Gut Strain of Bacillus subtilis. Genome Announc 1.
, 2013. A genomic signature and the identification of new sporulation genes. J Bacteriol 195(9):2101-15
, 2013. Evolution of intracellular compartmentalization. Biochem J 449(2):319-31
, 2012. The superfamily of heme-copper oxygen reductases: types and evolutionary considerations. Biochim Biophys Acta 1817(4):629-37
, 2011. Thousands of rab GTPases for the cell biologist. PLoS Comput Biol 7(10):e1002217
, 2011. Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8. Mol Cell 43(5):751-63
, 2011. Evolution: Tracing the origins of centrioles, cilia, and flagella. J Cell Biol 194(2):165-75
, 2011. A bioinformatics classifier and database for heme-copper oxygen reductases. PLoS One 6(4):e19117
, 2011. Loss of genetic redundancy in reductive genome evolution. PLoS Comput Biol 7(2):e1001082
, 2010. Stepwise evolution of the centriole-assembly pathway. J Cell Sci 123(Pt 9):1414-26
, 2009. Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia. Invest Ophthalmol Vis Sci 50(6):3009-16
, 2008. Evolution and dynamics of protein interactions and networks. Curr Opin Struct Biol 18(3):349-57
, 2008. The Ypt/Rab family and the evolution of trafficking in fungi. Traffic 9(1):27-38
, 2007. Multiple domain insertions and losses in the evolution of the Rab prenylation complex. BMC Evol Biol 7:140
, 2007. Evolution of protein complexes by duplication of homomeric interactions. Genome Biol 8(4):R51
, 2006. 3D complex: a structural classification of protein complexes. PLoS Comput Biol 2(11):e155
, 2006. The origins and evolution of functional modules: lessons from protein complexes. Philos Trans R Soc Lond B Biol Sci 361(1467):507-17
, 2005. The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat Struct Mol Biol 12(9):763-71
, 2005. Comparative genomics of trypanosomatid parasitic protozoa. Science 309(5733):404-9
, 2005. Novel specificities emerge by stepwise duplication of functional modules. Genome Res 15(4):552-9
, 2005. The relationship between domain duplication and recombination. J Mol Biol 346(1):355-65
, 2005. An exponential core in the heart of the yeast protein interaction network. Mol Biol Evol 22(3):421-5
, 2004. Functional evolution of the yeast protein interaction network. Mol Biol Evol 21(7):1171-6
, 2004. Detection of functional modules from protein interaction networks. Proteins 54(1):49-57
, 2003. Genome evolution reveals biochemical networks and functional modules. Proc Natl Acad Sci U S A 100(26):15428-33
, 2003. Classification schemes for protein structure and function. Nat Rev Genet 4(7):508-19
, 2003. Beyond 100 genomes. Genome Biol 4(5):402
, 2003. Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface. Biochem Biophys Res Commun 301(1):92-7
, 2002. Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase. Methods Mol Biol 189:157-65
, 2001. Evolution of the Rab family of small GTP-binding proteins. J Mol Biol 313(4):889-901
, 2001. Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease. FEBS Lett 498(2-3):197-200
, 2000. The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. J Mol Biol 301(4):1077-87
Publication list retrieved from NCBI using ImpactPubs
.